Addiction Sameness

Alcohol, Opiates, Fat and Sugar are all Addictive Substances: this blog is about that "addiction sameness".

Sunday, December 28, 2014

Product Labels

If you see any of these eight ingredients on a product's label, strike it from your grocery list immediately:

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Thursday, December 25, 2014

William S Burroughs - The.Junky's Christmas.

Uploaded on Jan 25, 2011

Fantastic narration by Burroughs about Danny, a poor unfortunate junkie who reveals his last remains of selflessness and humanity despite his urgent physical predicament.

The Junky's Christmas is a story by William S. Burroughs. It appears in the 1989 collection Interzone and on the 1993 album Spare Ass Annie and Other Tales. It was also made into a 1993 short claymation film directed by Nick Donkin and Melodie McDaniel. The film was produced by Francis Ford Coppola and was released by Koch Vision on DVD in North America on Nov. 21, 2006. Burroughs narrates the film and appears in live-action footage at the beginning and end of the film.
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William S. Burroughs (1914-1997)

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 The Junky's Christmas (1993)

Runtime: 21 min
Language: English
Country: USA
Color: Black and White

Director: Nick Donkin & Melodie McDaniel
Cast: William S. Burroughs ... Narrator (voice) 

Description: Burroughs takes down a book and reads us the story of Danny the Carwiper, who spends 
Christmas Day trying to score a fix, but finds the Christmas spirit instead. 
Francis Ford Coppola produced this short Claymation film based on William S. Burroughs excellent 
story The Junky's Christmas. Directed by Nick Donkin and Melodie McDaniel, it opens with live action 
footage of Burroughs as he begins his tale: 

It was Christmas Day and Danny the Car Wiper hit the street junksick and broke after seventy-two
 hours in the precinct jail. It was a clear bright day, but there was warmth in the sun. Danny shivered 
with an inner cold. He turned up the collar of his worn, greasy black overcoat. This beat benny wouldn't 
pawn for a deuce, he thought. 

Tuesday, December 23, 2014

The obesogen hypothesis

J Toxicol Environ Health B Crit Rev. 2011;14(5-7):423-48. doi: 10.1080/10937404.2011.578561.

The obesogen hypothesis: a shift of focus from the periphery to the hypothalamus.


The obesogen concept proposes that environmental contaminants may be contributing to the epidemic of obesity and its related pathology, metabolic disorder. 

The first references to such a notion appeared at the beginning of the current decade, with the hypothesis that the correlation between increasing incidence of obesity and enhanced industrial chemical production was not simply coincidental, but potentially causally related. 

The next event was the introduction of the term "obesogen" as representing an environmental pollutant that adversely affects various aspects of adipose tissue functions. 

More recently, the concept was extended to include substances that may modify metabolic balance at the central, hypothalamic level. 

The actions of two prime candidate obesogens, tributyltin (TBT) and tetrabromobisphenol A (TBBPA), acting at the central level are the main focus of this review. 

Having discussed the evidence for contaminant accumulation in the environment and in human tissues and the potential mechanisms of action, data are provided showing that these two widespread pollutants modify hypothalamic gene regulations. 

Our studies are based on maternal exposure and measurement of effects in the progeny, mainly based on in vivo gene reporter assays. Such models are obviously pertinent to testing current hypotheses that propose that early exposure might exert effects on later development and physiological functions. 

The potential molecular mechanisms involved are discussed, as are the broader physiological consequences of these hypothalamic dysregulations.
[PubMed - indexed for MEDLINE]

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