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William S Burroughs - The.Junky's Christmas.

Uploaded on Jan 25, 2011

Fantastic narration by Burroughs about Danny, a poor unfortunate junkie who reveals his last remains of selflessness and humanity despite his urgent physical predicament.

The Junky's Christmas is a story by William S. Burroughs. It appears in the 1989 collection Interzone and on the 1993 album Spare Ass Annie and Other Tales. It was also made into a 1993 short claymation film directed by Nick Donkin and Melodie McDaniel. The film was produced by Francis Ford Coppola and was released by Koch Vision on DVD in North America on Nov. 21, 2006. Burroughs narrates the film and appears in live-action footage at the beginning and end of the film.

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William S. Burroughs (1914-1997)  Back to William S. Burroughs  The Junky's Christmas (1993) Runtime: 21 min Language: English Country: USA Color: Black and White Director: Nick Donkin & Melodie McDaniel Cast: William S. Burroughs ... Narrator (voice)  Description: Burroughs takes down a book and reads us the story of Danny the Carwiper, who spends  Christmas Day trying to score a fix, but finds the Christmas spirit instead.  Francis Ford Coppola produced this short Claymation film based on William S. Burroughs excellent  story The Junky's Christmas. Directed by Nick Donkin and Melodie McDaniel, it opens with live action  footage of Burroughs as he begins his tale:  It was Christmas Day and Danny the Car Wiper hit the street junksick and broke after seventy-two  hours in the precinct jail. It was a clear bright day, but there was warmth in the sun. Danny shivered  with an inner cold. He turned up the collar of his worn, greasy black overcoat. This beat benny wouldn't  pawn for a deuce, he thought.  Link: http://youtu.be/u6kHN92Yv48

The obesogen hypothesis

J Toxicol Environ Health B Crit Rev. 2011;14(5-7):423-48. doi: 10.1080/10937404.2011.578561.

The obesogen hypothesis: a shift of focus from the periphery to the hypothalamus.

Decherf S¹, Demeneix BA.

Author information

Abstract

The obesogen concept proposes that environmental contaminants may be contributing to the epidemic of obesity and its related pathology, metabolic disorder. 


The first references to such a notion appeared at the beginning of the current decade, with the hypothesis that the correlation between increasing incidence of obesity and enhanced industrial chemical production was not simply coincidental, but potentially causally related. 

The next event was the introduction of the term "obesogen" as representing an environmental pollutant that adversely affects various aspects of adipose tissue functions. 

More recently, the concept was extended to include substances that may modify metabolic balance at the central, hypothalamic level. 

The actions of two prime candidate obesogens, tributyltin (TBT) and tetrabromobisphenol A (TBBPA), acting at the central level are the main focus of this review. 

Having discussed the evidence for contaminant accumulation in the environment and in human tissues and the potential mechanisms of action, data are provided showing that these two widespread pollutants modify hypothalamic gene regulations. 

Our studies are based on maternal exposure and measurement of effects in the progeny, mainly based on in vivo gene reporter assays. Such models are obviously pertinent to testing current hypotheses that propose that early exposure might exert effects on later development and physiological functions. 

The potential molecular mechanisms involved are discussed, as are the broader physiological consequences of these hypothalamic dysregulations.

PMID:

21790320

[PubMed - indexed for MEDLINE]

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